Carbon–carbon bond formation and green chemistry: one dream and 30 years hence

Carbon–carbon bond formation is the core of organic synthesis, in which organometallic reagents play key role forms 1,2-nucleophilic additions, conjugate and transition-metal catalyzed cross-couplings. These reactions have enabled production a wide range molecules our society. Despite enormous power chemical they inherent drawbacks eyes future sustainability. This account summarizes efforts over past three decades on exploration new scientific means to overcome limitations these classical reactions.